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KMID : 0043320090320040481
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Archives of Pharmacal Research
2009 Volume.32 No. 4 p.481 ~ p.487
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Synthesis and Docking Studies of New 1,4-Dihydropyridines Containing 4-(5)-Chloro-2-ethyl-5-(4)-Imidazolyl Substituent as Novel Calcium Channel Agonist
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Shafiee Abbas
Iman Maryam
Nematollahi Ali Reza
Davood Asghar
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Abstract
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1,4-Dihydropyridines have been recognized as calcium channel agonist. Three new analogues of Bay K8644 in which the ortho trifluromethyl phenyl group at position 4 is replaced by the 4-(5)-Chloro-2-ethyl-5-(4)-imidazolyl substituent, were designed and synthesized as calcium channel agonist. For this propose, the structures of designed compounds were drawn by HYPERCHEM program. Conformations of the compounds were optimized through semiempirical method followed by PM3 calculation. Then the crystalin stucture of L-type calcium channel was obtained from the Protein Data Bank (PDB) server. Docking calculations were carried out using Auto-Dock.4 program. The good interaction of our 1,4-DHP derivatives showed that they can be as possible calcium channel agonist agents. Finally compounds were synthesized according to a modified Hantzsch condensation procedure.
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KEYWORD
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Calcium channel agonist, Dihydropyridines, Chloroimidazole, Nifedipine analogues, (S)Bay K 8644
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